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左卡尼汀对慢性充血性心力衰竭患者血清炎症因子的影响 被引量:4

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摘要 目的:探讨左卡尼汀对慢性充血性心力衰竭(CHF)患者血清炎症因子的影响,并观察疗效和安全性。方法:80例CHF住院患者按住院号顺序分为观察组与对照组。对照组患者入院后予以强心、利尿和扩张血管等常规治疗。观察组患者在此基础上加用左卡尼汀注射液3.0 g,ivd,qd,连用2周。比较两组患者治疗前后血清炎症因子水平,并观察其疗效及不良反应。结果:治疗2周后,两组患者血清hs-CRP、IL-8和IL-18水平均有明显下降(P<0.05和P<0.01),且与对照组比较,观察组下降更明显(P<0.05)。观察组总有效率明显高于对照组(P<0.05)。两组患者治疗期间未发生明显的药品不良反应。结论:左卡尼汀降低慢性充血性心力衰竭患者血清炎症因子hs-CRP、IL-8和IL-18水平,具有较好的临床疗效和安全性。
作者 张雅红
出处 《中国药师》 CAS 2013年第8期1214-1215,共2页 China Pharmacist
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