白细胞介素-4、白细胞介素-12和白细胞介素-18与乙型肝炎病毒宫内感染相关性研究

Study on the relationship between interleukin-4,interleukin-12 and interleukin-18 and intrauterine infection of hepatitis B virus

目的研究白细胞介素（IL）-4、IL-12和IL-18与乙型肝炎病毒（HBV）宫内感染的相关性，为其预防和治疗提供理论依据。方法选择HBsAg阳性合并HBV宫内感染的40例孕妇作为研究组，选择HBsAg阳性未合并HBV宫内感染的80例孕妇作为对照组，比较两组IL_4、IL-12和IL-18水平。结果研究组IL-4水平为（51.56±7.86）ng／L，明显高于对照组的（31.67±8.64）ng／L；研究组IL-18和IL-12水平分别为（803.45±132.64）、（627.87±134.38）ng／L，明显低于对照组的（904.87±231.86）、（734.78±165.67）ng／L，差异均有统计学意义（P〈0.01）。结论IL-4、IL-12和IL-18与HBV宫内感染密切相关，IL-4水平上升，IL-18和IL-12水平下降可能导致HBsAg阳性孕妇发生HBV宫内感染。

Objective To study the relationship between interleukin（IL）-4, IL-12 and 1L-18 and intrauterine infection of hepatitis B virus （HBV）, in order to provide the basis for prevention and treatment. Methods Forty pregnant women with positive HBsAg and intrauterine infection of HBV were selected as study group, and 80 pregnant women with positive HBsAg and non-intrauterine infection of HBV were selected as control group. The levels of IL-4,IL-12,IL-18 were compared. Results The level of IL-4 was （51.56±7.86） ng/L in study group, which was higher than that in control group [（31.67±8.64） ng/L], and there was significant difference between two groups （P〈0.01）. The levels of IL-12 and IL-18 were （803.45±132.64）, （627.87±134.38） ng/L in study group, which werelower than that in control group [（904.87 ＋ 231.86）, （734.78±165.67） ng/L], and there w ere significant differences between two groups （P〈0.01）. Conclusions The levels of IL-4, IL-12, IL-18 are correlated with intrauterine infection of HBV. The increase of IL-4 and the decrease of IL-18, IL-12 may lead to positive HBsAg pregnant women happening intrauterine HBV infection.