全肿瘤细胞抗原研究进展

Processing in Whole Tumor Cells Antigens for Cancer Immunotherapy

全肿瘤细胞抗原在肿瘤预防和免疫治疗上具有潜在的应用前景,其能突破肿瘤单一抗原的局限性,并能诱导激活细胞毒性T淋巴细胞和CD4+T辅助细胞。对全肿瘤细胞抗原的种类、负载全肿瘤细胞抗原的DC细胞、全肿瘤细胞抗原修饰与免疫增强作用等方面的研究进行综述。

Whole tumor cell（WTC）as tumor antigens is a very promising alternative in tumor immune protection and immunotherapy,which can theoretically eliminate some important limitations in vaccine development.Whole tumor cells express a whole array of tumor associated antigens（TAAs）,and simultaneously can induce CTLs and CD4＋ T helper cell activation.In this paper,some recent proceedings and current preparing methods of whole tumor cell antigens were reviewed including some types of WTC antigens,DC cells loaded by WTC antigens,and modification and immune enhancement of WTC antigens.