氟比洛芬酯对下腹部手术患儿超前镇痛效果的临床观察

The pre-analgesic efficacy of flurbiprofen axetil in children undergoing lower abdomen surgery

目的观察氟比洛芬酯对下腹部手术患儿超前镇痛的效果。方法拟行下腹部手术的患儿40例,随机分为氟比洛芬酯组(F组)和对照组(N组),每组20例。F组在手术开始前15min,将氟比洛芬酯1.25mg/kg用生理盐水稀释至20ml缓慢静脉注射;N组静脉注射等量的生理盐水。记录术后2、6、12、24h患儿VAS评分;观察并记录两组术后镇痛药应用次数及人数,及可能出现的不良反应,如嗜睡、恶心呕吐、呼吸抑制、异常出血、皮肤瘙痒等。结果与N组比较,F组术后2、6、12h时间点VAS评分明显降低(P<0.05),术后24h时VAS评分两组间比较差异无统计学意义(P>0.05);两组不良反应发生率的差异无统计学意义(P>0.05);F组术后镇痛药应用次数及术后用镇痛药人数明显少于N组(P<0.05)。结论氟比洛芬酯具有较强的超前镇痛作用,使手术镇痛维持时间延长,减少了术后其他镇痛药物的应用。

Objective To observe the pre-analgesic efficacy of flurbiprofen in children undergoing lower abdomen surgeries. Methods Forty children with ASA Ⅰ or Ⅱ scheduled for lower abdomen surgeries were randomized into two groups （n=20 in each）： the N group and the K group. The F group received flurbiprofen 1.25 mg/kg 15 min before opera-tion. The pain intensity was scored with visual analog scale （VAS） at 2,6,12 and 24 h after operation. The time and the bo-luses of analgesic drugs were recorded after operation. The number of analgesic drugs application in the two groups and the rate of side effects were recorded. Results Compared with group N, the scores in Groups F were significantly lower at 2,6,12 h after operation （P 〈 0.05）. No significant difference in the VAS was observed between the two groups at 24 h after operation （P 〉 0.05）. The rate of side effects had no significant difference between the two groups （P 〉 0.05）. The number of analgesic drugs application of the F group was less than the N group （P 〈 0.05）. Conclusion Flurbiprofen may be safe and effective to achieve satisfactory pre-analgesia effect in children. It can prolong the analgesic time after opera-tion and decrease the use of analgesic drugs.