HLA抗体在北京地区无偿献血已育妇女的分布情况

Prevalence of HLA antibodies in parous women blood donors in Beijing

目的了解HLA抗体在北京地区无偿献血已育妇女中的分布情况。方法招募无偿献血群体中有生产史而无输血史的妇女95名,使用HLA抗体筛选试剂进行检测。结果 95份血清样本中,HLA抗体阳性26份,阳性率为27.4%。其中怀孕1次、2次、3次及4次以上的人群中,HLA抗体的阳性率分别为18.5%、29.6%、31.0%和33.3%。结论无偿献血已育妇女中HLA抗体的阳性比例与国外文献报道相近,随怀孕次数增加,HLA抗体阳性率呈升高趋势。对无偿献血已育妇女进行HLA抗体筛查十分必要。

Objective To assess the prevalence of HLA antibodies in parous women blood donors. Methods Serum samples from 95 parous women blood donors were collected, and Lab-Screen Mixed （LSM12） reagents were used to detect the HLA antibodies. Results A total of 95 donors were tested. The number of positive samples was 26, the positiv-ity rate was 27.4%. HLA antibodies positivity rates varied for the history of pregnancy. Conclusion HLA antibodies posi-tivity rates in parous women donors are similar with those reported in foreign women. HLA antibodies positivity rates ele-vates with the increasing number of pregnancy, but there is no statistical significant difference.