中老年人群颈动脉内中膜厚度分布特征及相关因素分析

Distribution Characteristics and Related Factors of Carotid Intima-Media Thickness in Middle and Elder Aged Population

目的：探讨中老年人群颈动脉内中膜厚度分布特征的现状及其相关因素。方法：于2012—10至2012—11，对中美心血管病和心肺疾病流行病学合作研究中的石景山人群复查心血管病危险因素并进行颈动脉超声检查，以此横断面数据进行分析。结果：共计调查1345人。其中1277人数据完整者纳入分析，年龄52。88岁。颈动脉内中膜厚度平均值为（0．68±0．10）mm，两性均随年龄而增加，趋势分析具有统计学意义（P〈0．001）。各年龄阶段颈动脉内中膜平均厚度男性均大于女性（P〈0．01）。多因素分析结果显示：男女两性颈动脉内中膜厚度随着年龄、收缩压、血糖、甘油三酯和体质指数的增加而增加（P〈0．05）。结论：除年龄和性别外，血压、血糖、血脂和肥胖与中老年人群颈动脉内中膜厚度密切相关，应作为心血管病防治的重点。

Objective： To explore the current distribution characteristics and related factors of carotid intima-media thickness in middle and elder aged population. Methods： From October to November 2012, the cross-sectional examination for cardiovascular risk factors and B-mode ultrasound imaging on carotid arteries were performed in participants at Shijingshan area in Beijing by China-US （PRC-USA） collaborative study. Results： The study investigated a total of 1345 people. There 1277 subjects at the age of （52-88） years with complete information were analyzed. The mean intima-media thickness （IMT） of carotid arteries was （0.68 ±0.10） mm. The carotid IMT increased accordingly with the elevated age in both male and female genders and the trend analysis had the statistic meaning, P〈0.001. The mean IMT in male was thicker than female at all age stages, P〈0.01. Multivariate analysis presented that the mean IMT increased with the elevated age, systolic blood pressure, triglyceride and body mass index, P〈0.05. Conclusion： In addition to age and gender, the blood pressure, glucose, lipids and obesity were related to carotid intima-media thickness, and those factors should be focused for cardiovascular disease prevention and treatment.