X线造影剂对肺阻力动脉张力的影响

Effects of radiographic contrast media on the tension of isolated pulmonary resistance arteries

目的 观察并比较临床上常用的四类X线造影剂对肺阻力动脉张力的影响。方法 取内径为0.3-0.6毫米的大鼠肺小动脉,通过自动血管Myograph仪连续地记录血管条张力,观察10、20、40、80、150或200mgI/ml等浓度的四种不同类型X线造影剂(泛影葡胺、低渗显影葡胺、优维显、伊索显)及甘露醇渗透压对照溶液对肺阻力动脉张力的影响。结果 所有四种造影剂均引起肺阻力动脉血管条的双相性张力改变,包括初始一过性血管舒张及随后持续的血管收缩。在甘露醇对照组肺阻力动脉仅显示持续的血管收缩而无血管舒张。造影剂对肺阻力动脉张力的影响程度依次为泛影葡胺、优维显、低渗显影葡胺、伊索显。结论 X线造影剂可导致肺阻力动脉张力的显著变化,高渗离子型造影剂的作用最大,等渗非离子型造影剂的作用最小。

Purpose To study the direct effects of radiographic contrast media (RCM) on the tension of isolated pulmonary resistance arteries and compare the effects caused by four different kinds of RCM ( diatrizoate, ioxaglate, iopromide, iotrolan) . Methods Resistancy pulmonary arteries (0.3 - 0.6mm in diameter) from rats were mounted in a vessel myograph and vessel tension was recorded. The effects of 10,20,40,80,150,200, 250mgl/ml of diatrizoate,ioxaglate, iopromide, iotrolan and their mannitol osmolar control were studied. Results RCM caused biphasic changes in pulmonary resistance arteries tension, with slight transient dilatation followed by sustained constriction, which varied depending on the type and concentration of RCM. The order of RCM vasoconstriction potency was as follow; diatrizoate > iopromide > ioxaglate > iotrolan. Conclusion RCM could caused significant changes of the tension of pulmonary resistance arteries. High osmolar ionic RCM was the most vaso - active and isoosmolar non - ionic RCM was the least vaso - active.