摘要
目的探讨阿德福韦酯对慢性乙肝患者血清HBV DNA及HBsAg的影响。方法47例慢性乙型肝炎患者,用阿德福韦酯治疗,分别在治疗的12、24和48周时应用荧光定量聚合酶链反应法检测慢性乙肝患者血清HBV DNA水平,应用ELISA法检测慢性乙肝患者血清HBsAg水平。结果经治疗12周后,慢性乙肝患者血清HBV DNA与HBsAg均较治疗前明显下降(P<0.05),并且随着阿德福韦酯治疗时间的延长,慢性乙肝患者血清HBV DNA与HBsAg水平持续下降。第24周时血清HBV DNA下降率为基线的46.07%,在第48周时,血清HBV DNA下降率为基线的54.21%。第24周时血清HBsAg下降率为基线的47.55%,在第48周时,血清HBsAg下降率为基线的52.45%。结论阿德福韦酯治疗慢性乙型肝炎的疗效显著,能有效地抑制病毒复制。
Objective To investigate the effect of adefovir dipivoxil on HBV DNA and HBsAg in serum of patients with chronic hepatitis B. Methods The 47 patients with chronic hepatitis B were treated with adefovir dipivoxil for 48 weeks. The levels of HBV DNA were detected by metheod of fluorescence quantitative polymerase chain reaction at 12th, 24th, 48th week of treatment. The levels of HBsAg were detected by ELISA. Results The levels of HBV DNA and HBsAg in serum of pa- tients with chronic hepatitis B were decreased significantly after treatment with adefovir dipivoxil for 12 weeks （P〈0.05）. The levels of HBV DNA and HBsAg were continued to drop rate along with the progress of treatment. The levels of HBV DNA were 46.07% and 54.21% 24th week and 48th week of treatment, that of HBsAg were 47.55% and 52.45% at 24th week and 48th week of treatment. Conclusion Adefovir dipivoxil can effectively inhibit HBV replication and improve liver function of chron- ic hepatitis B patients.
出处
《中国热带医学》
CAS
2013年第7期897-898,共2页
China Tropical Medicine
