摘要
目的检测趋化因子CXCL12及其受体CXCR4在子宫内膜癌组织中的表达水平,探讨其与子宫内膜癌患者的临床病理特征和预后的关系。方法采用组织芯片技术和免疫组化方法检测子宫内膜癌组织中CXCL12、CXCR4表达水平,并分析它们与FIGO分期、细胞分化程度、淋巴结转移、病理类型及年龄等临床病理特征及总生存率的关系。结果子宫内膜癌组织中CXCL12、CXCR4的表达水平均显著高于正常子宫内膜组,且二者在子宫内膜癌组的上调表达呈正相关。CXCR4的表达与子宫内膜癌细胞分化程度呈正相关(P<0.05)。CXCL12、CXCR4均不影响子宫内膜癌患者的生存率(P>0.05)。结论 CXCL12和CXCR4可能在子宫内膜癌的发生、发展中发挥生物学作用。
Objective To observe the translations of chemokine CXCL12 and its receptor CXCR4 in endometrial carcino- ma, and to evaluate their significance in clinical pathologic features and prognosis of endometrial carcinoma. Methods We examined the translations of CXCL12 and CXCR4 in human endometrial carcinoma tissue and normal endometrial tis- sue by tissue chip technique and immunochemical staining. Then we analyzed the relationship between the expression of CXCL12, CXCR4 and FIGO stage, the grade of differentiation, metastasis of lymph nodes, type of pathology, age and prognosis of patient from endometrial carcinoma. Results The chemokine pair CXCL12/CXCR4 was translated in nor- mal endometrial tissue. The expression of CXCL12 and CXCR4 increased in endometrial carcinoma significantly, and their up-regulation correlated positively with each other. The expression of CXCR4 correlated significantly with histological grade of endometrial carcinoma, but patients with CXCL12 or CXCR4 expression had similar overall survival with those without them. Conclusion The interactions between CXCL12 and CXCR4 may play important roles in the evolution and progression of endometrial carcinoma.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2013年第8期653-656,共4页
Chinese Journal of Practical Gynecology and Obstetrics
基金
国家自然科学基金青年基金(30700763)
山东省优秀中青年科学家科研奖励基金(BS2009SW002)
