职业性锰暴露对男性工人血浆脑源性神经营养因子含量的影响

Effect of Occupational Manganese Exposure on Plasma Brain-Derived Neurotrophic Factor Levels in Male Workers

[目的]通过测定职业性锰暴露男性工人血浆脑源性神经营养因子(BDNF)水平,探讨锰暴露对工人血浆BDNF含量的影响。[方法]选择广西某锰冶炼厂179名男性工人为暴露组,按锰累积暴露指数(CEI)分为低暴露组(CEI<2.000,84名)和高暴露组(CEI≥2.000,95名),以同一地区某糖厂96名男性工人为对照组,对其进行一般情况调查和血浆BDNF含量的测定。[结果]控制年龄、民族等协变量后,该厂锰作业男性工人CEI与血浆BDNF含量呈负相关(r=-0.200,P<0.05);两个暴露组人群血浆BDNF含量均低于对照组工人(均P<0.01),高暴露组工人低于低暴露组(P<0.05)。[结论]职业性锰暴露可降低锰冶炼厂男性工人的血浆BDNF水平。

[ Objective ] To determine the plasma brain-derived neurotrophic factor （BDNF） levels in male workers with manganese （Mn） exposure at workplace and explore the effect of occupational Mn exposure on plasma BDNF levels. [ Methods ] A total of 179 male workers of a manganese smelter in Guangxi were chosen as exposure group, and divided into low （84 workers） and high （95 workers） Mn exposure groups by cumulative exposure index （CEI） of Mn. Another 96 male workers of a sugar refinery in the same district were selected as control group. All participants received questionnaires on general information and determination of plasma BDNF. [ Results ~ After adjusted for age and nation, a negative correlation between the plasma BDNF and the Mn exposure were identified （r=-0.200, P 〈 0.05）. The plasma BDNF levels of the two exposure groups were statistically lower than that of the control group （P 〈 0.01）, and the high Mn exposure group reported a lower level of BDNF than the low Mn exposure group （P〈0.05）. [ Conclusion ] Occupational Mn exposure may decrease plasma BDNF levels in male Mn smelting workers.