P—ERG与青光眼杯盘比相关性研究

The correlative study between P--ERG and Cup/Disk(C/D) of glaucoma

目的探讨原发开角型青光眼的杯盘比与Ｐ—ＥＲＧ的相关性。方法依据原发开角型青光眼患者的杯盘比值大小将其划分为三组，（①Ｃ／Ｄ≤０．３；②≤０．６；③＞０．６），利用视觉电生理检测系统分别检测Ｐ—ＥＲＧ。结果原发开角型青光眼图形视网膜电图ｂ波幅值与杯盘比值呈现显著负相关关系，当Ｃ／Ｄ尚处于正常范围大小时，ｂ波幅值即可发生具有临床意义的降低。另外，三组间的ｂ波幅值亦有显著性差异。结论 ｂ波幅值降低是比Ｃ／Ｄ改变更为敏感的早期临床诊断的指标，ｂ波幅值可反映视功能及视乳头的损害程度。因而 Ｐ—ＥＲＧ检测可在疑似原发开角型青光眼患者中作筛选及辅助诊断之用，也可在青光眼随访中发挥作用。

Objective To explore the correlation between P - ERG and Cup/Disk (C/D) of glaucoma. Methods in this study primary open-angel glaucoma patients were divided into three groups as follows according to their data of C/D: ①C/D<0. 3;②C/D<0. 6; ③C/D>0. 6. Meanwhile, we made use of visual electrophysiology monitoring system to monitor P--ERG respectively. Results it had been shown that there was a signficant negative correlation between b wave scope date of pattern electroretinogram of primary open-angel glaucoma and their date of C/D. When the date of C/D was in the normal range, b wave scope date showed a decrease which had clinical significance. In addition, the data of b wave scope also had a significant deference among the above three groups. The results suggest that the decrease of b wave scope is a more sensitive marker in comparison with the change of C/D data in the early clinical diagnosis of glaucoma. Conclusion The data of b wave scope can reflect the damage degree of optic function and optic disk. We conclude that P-ERG monitoring system should be taken into account in choosing and supplementary diagnosing those patients who is in suspicion of primary open -angel glaucoma and also P-ERG monitoring system can play a role in the follow-up of glaucoma.