血清RBP和尿NAG在早期2型糖尿病肾病诊断中的意义

The value of serum retinol binding protein and urinary N-acctyl-glucosaminidase in the diagnosis of early-stage nephropathy in type 2 diabetes melitus

目的:探讨检测血清视黄醇结合蛋白(sRBP)和尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)在早期2型糖尿病肾病诊断中的价值。方法:选择120例2型糖尿病患者,以尿微量白蛋白(mALB)/尿肌酐(UCr)比值分组,mALB/UCr<30 mg/g为对照组,共60例;mALB/UCr在30～299 mg/g为早期2型糖尿病肾病组(观察组),共60例。比较2组患者的sRBP、尿NAG水平及其阳性检出率。结果:观察组sRBP和尿NAG水平均较对照组显著升高(P<0.01);观察组2种指标的阳性率均高于对照组(P<0.01);但观察组2种指标的阳性率差异无统计学意义(P>0.05);观察组sRBP和尿NAG的水平与尿mALB的水平呈正相关关系(P<0.01)。结论:检测sRBP、尿NAG可作为诊断早期2型糖尿病肾损害的敏感指标,对早期2型糖尿病肾病的诊断具有重要的价值。

Objective： To investigate the value of serum retinol binding protein （sRBP） and urinary N-acctyl-glucosaminidase （NAG） in the diagnosis of early-stage nephropathy in type 2 diabetes melitus. Methods：According to the ratio of microalbuminuria（mALB） to urine creatinine （UCr）, 120 patients with type 2 diabetes were divided into the control group（60 cases, mALB/UCr less than 30 mg/g） and observation group（60 cases, mALB/UCr from 30 to 299 mg/g）. The levels of sRBP and urinary NAG of all patients were detected. Results：The levels of sRBP and urinary NAG and their detection positive rates in observation group were significantly higher than those in control group（ P 〈 0.01 ）, but the difference of the detection positive rate between the two indicators in observation group had no statistical significance. The levels of sRBP and urinary NAG were positively correlated to the levels of urinary mALB in observation group （ P 〈 0.01 ）. Conclusions ： The levels of sRBP and urinary NAG can be a sensitive index for identifying the early renal damage of type 2 diabetes,which has important value in the diagnosis of early-stage nephropathy in type 2 diabetes melitus.