肺癌患者化疗前后血浆D-二聚体测定的临床意义

The Prognostic Significance of Plasma D-dimer Concentration in Patients with Lung Cancer

目的 :探讨肺癌患者血浆D -二聚体水平与化疗疗效的关系。方法 :采用胶体金方法测定 35例肺癌患者化疗前后血浆D -二聚体的含量。结果 :肺癌患者化疗前血浆D -二聚体水平显著高于正常人 (P <0 0 0 1) ,化疗后有效组 (CR +PR)D -二聚体含量显著低于化疗前 (P <0 0 0 1) ,化疗后稳定组D -二聚体含量与化疗前相比 ,差异无显著性 (P <0 0 5) ,化疗后进展组D -二聚体含量明显高于化疗前 (P <0 0 0 1)。结论 :血浆D -二聚体的水平高低可作为肺癌判断预后。

Objective:To investigate the relationship between plasma Ddimer and the effect of chemotherapy of patients with lung cancer.Methods:Colloidal gold was used to determine the Ddimer concentration in plasma samples.Results:The level of Ddimer in 35 new lung cancer patients was significantly higher than that of normal control(P<0001).After chemotherapy,the level of Ddimer in patients with CR and PR was markedly reduced(P<0001),but increased(P<0001)in PD cases ,and not changed in SD patients.Conclusions:The level of plasma Ddimer can be used in predicting the effects of chemotherapy of lung cancer.