乳腺癌中微血管密度及bFGF表达的意义

Clinical Significance of microvessel density and expression of bFGF in breast carcinoma

目的 研究肿瘤中微血管密度 (MVD)和肿瘤碱性成纤维生长因子 (bFGF)的表达水平在乳腺癌中的临床意义。方法 对 32例手术切除的乳腺癌标本进行连续切片 ,分别做HE染色 ,F -Ⅷ相关抗原和bFGF免疫组织化学染色 ,根据Weidner法进行MVD的测定。结果 32例中 ,bFGF阳性者 1 8例 ,表达率为 5 6 3% ,阳性表达者MVD记数为41 5 5± 1 4 44 ,肿瘤直径大于 5cm时 ,肿瘤微血管密度明显增高。结论 bFGF在肿瘤血管形成和肿瘤生长中起重要作用 ,而肿瘤微血管密度可以做为评定乳腺癌预后的一项重要指标。

Objective To study the clinicopathological significance of tumor microvessel density (MVD)and expression of tumor basic fibroblastic growth factor (bFGF)in breast carcinoma.Methods Specimens of 32 cases of breast cancer were cut into serial sectings.Routine histological and immunohistochemical staining was used to detect the MVD by Weidner method.Results Of all 32 cases 18 were positive,expression rateio was 56 3%,and the count of positive expression was 41 55±14 55.The MVD signifiantly increased when the tumor was greater than 5 cm in diameter.Conclusions bFGF plays an important role in the formation of tumor microvessels and the development of tumor.The MVD is a useful criterion for evaluating the prognosis of breast cancer.