肺癌高钙血症与异位合成1,25二羟胆钙化醇的初步研究

Study of 1,25-Dihydroxycholecalciferol and Lung Cancerassociated Hypercalcemia

目的 :探讨肺癌组织是否具有异位合成 1,2 5二羟胆钙化醇 ( 1,2 5dihydroxycholecalciferol ,DHCC)的能力及其在肺癌高钙血症发病中的作用。方法 :采用改良的放射受体法检测 60例术中切除的肺癌组织 ,相邻正常肺组织及患者血清中DHCC含量。结果 :肺癌组织DHCC含量为 ( 80 13± 2 1 14)pg/g ,正常肺组织DHCC含量为 ( 58 36± 16 69)pg/g ,前者明显高于后者 (P <0 .0 1) ,其中鳞癌组织DHCC含量明显高于非鳞癌组织含量 (P <0 0 1) ,患者血清DHCC含量为 ( 37 71± 9 2 4 )pg/ml,在正常范围内。结论 :提示肺癌组织具有异位合成DHCC的能力 ,尤以鳞癌为主 。

Objective:To study if the lung tumor tissues have the ability to synthesis 125dihydroxycholecalciferol(DHCC) and the effect of DHCC taken in the pathogenesis of lung cancerassociated hypercalcemia.Methods:A modificated method of DHCC radioreceptor assay(RRA) was used to detect DHCC concentrations of serum, tumor tissues and normal lung tissues in patients with lung cancer.Results:The DHCC consentration of tumor tissue is (8013±2114) pg/g,and normal lung tissue is (5836±1669) pg/g. The difference is significant(p<001). In tumoral tissue, the DHCC concentration of squamous cell carcinoma is higher than that of nonsquamous cell carcinoma(p<001).The DHCC concentration of serum of lung cancer patients is (377 ±924) pg/ml.Conclusions:The lung tumor tissue, especially squamous cell carinoma tissue can synthesis DHCC. But the concentrstion of serum in lung cancer patients is in normal range. This result suggests that DHCC doesn't play the central role in the pathogenesis of lung cancerassociated hypercalcemia.