胃癌患者血清睾酮变化的临床意义

Clinical Significance of Serum Testosterone Changes in Patients with Gastric Carcioma

目的 :本文观察了 70例进展期胃癌手术前后血清睾酮的变化。方法 :采用放射性免疫化学方法测定进展期胃癌和对照组手术前后血清睾酮的变化。结果 :52例男性胃癌患者手术前血清睾酮( 32 63± 5 62 )nmol/L , x±s)与良性疾病对照组 ( 4 2 92± 8 93)nmol/L相比明显降低 (P <0 0 1) ;手术后 3个月复查血清睾酮 ( 4 0 84± 6 53)nmol/L比术前升高 (P <0 0 1) ;与良性疾病对照组入院时已无明显差别 (P >0 0 5) ;术后复发组血清睾酮 ( 2 8 66± 8 74 )nmol/L与术后 3个月时相比再次下降 (P <0 0 1)。女性胃癌患者术后血清睾酮 ( 2 32± 0 4 7)nmol/L比术前 ( 1 73± 0 34 )nmol/L也明显升高 (P<0 0 1)。结论 :结果提示血清睾酮可以做为胃癌诊断。

Objective:To study changes of testosterone before and after operation in 70 patients with progressive stage gastric carcinoma.Methods:Radioimmuoassay was used in 42 controls and 70 cases of progressive gastric carcinoma before and after operation.Results:The preoperation serum testosterone level of the male patients with gastric carcinoma (3263±562 nmol/L,+s) was lower than that of benign desease(P<001).Serum testosterone 3 months after operation (4084±653 nmol/L) was higher than that of preoperation (P<001),and there was no statistic significance with benign disease (P>005).Serum testosterone in recurrence cases after operation(2866±874 nmol/L) was lower than that 3 months after operation(P<001).Serum testosterone in female patients with gastric carcinoma(232±047 nmol/L) was higher than that of preoperation(173±034) nmol/L,(P<001).Conclusions:Serum testosterone level was a helpful indication in diagnosis,treatment and recurrence observation in patients with gastric carcinoma.