Livin蛋白和FHIT蛋白在宫颈癌中的表达及意义

Expression and Significance of Livin and FHIT Protein in Cervical Carcinoma

目的：探讨Livin蛋白和FHIT蛋白在宫颈癌组织中的表达和意义。方法：用免疫组化sP法检测12例正常宫颈组织、56例宫颈癌组织中Livin蛋白和FHIT蛋白的表达情况，并结合临床病理资料进行分析。结果：Livin蛋白在宫颈癌组织中的阳性表达率明显高于正常宫颈组织，而FHIT蛋白在宫颈癌组织中的阳性表达率明显低于在正常宫颈组织，差异均有统计学意义（P〈0．05）。在宫颈癌组织中，Livin蛋白阳性表达率随临床分期、病理分级的升高而逐渐升高，有淋巴结转移者高于无淋巴结转移者；而FHIT蛋白阳性表达率随临床分期、病理分级的升高而减低，有淋巴结转移者低于无淋巴结转移者，差异均有统计学意义（P〈0．01）。在宫颈癌组织中，Livin蛋白和FHIT蛋白表达呈负相关（P〈0．05）。结论：Livin蛋白和FHIT蛋白的异常表达可能在宫颈癌的发生、发展中有着重要的作用。联合检测二者在宫颈癌中的表达情况，可为宫颈癌的早期诊断、靶向治疗及预后判断提供重要的理论依据。

Objective：To study the expression and significance of Livin protein and FHIT protein in cervical carcinoma. Methods：Immunohistochemical sp staining method was used to detect the expression of Livin protein and FHIT protein in 12 cases of normal cervical epithelium, and 56 cases of cervical carcinoma, combined with clinical pathology data for analysis. Results： The expression of Livin protein was apparently high- er in cervical carcinoma than normal cervical epithelium, while the expression of FHIT protein was apparently lower in cervical carcinoma than normal cervical epithelium （ P 〈 O. 05 ）. In cervical carcinoma Livin protein positive expression rate along with the clinical stage, pathologic stage increased with the rise, lymphatic metas- tasis was higher than non -lymph node metastasis ; FHIT protein positive expression dropped in company with the elevation of the clinical stage, pathologic stage increased, lymph metastasis was lower than non - lymph node metastasis, the difference was statistically significant （P 〈 0.01 ）. Negative correlation was also found be- tween Livin and FHIT protein expression in cervical carcinoma. （ P 〈 0.05 ）. Conclusions ： The abnormal ex- pression of Livin protein and FHIT protein may play an important role in the development of the occurrence of cervical cancer. Joint detection of both expressions in cervical cancer provides theory basis in early diagnosis of cervical cancer, targeted therapy and prognosis judgment.