动脉灌注化疗治疗晚期鼻咽癌80例疗效分析

Evaluation of Intra-Arterial Chemotherapy in Treatment of 80 Cases of Advanced Nasopharyngeal Carcinoma

目的 :观察颞浅动脉插管灌注化疗对晚期鼻咽癌的疗效和不良反应。方法 :选择单侧或双侧颞浅动脉插管 ,用TDP方案 :THP 2 0mg ,d1,DDP 30mg ,d2～ 4 ;PYM 8mg ,d5～ 9。 2 1天为 1周期 ,满 2个周期者进行疗效评估。结果 :原发灶有效率 90 % ( 72 / 80 ) ,其中CR 2 0 % ( 16/ 80 ) ,PR 70 % ( 56/ 80 )。颈淋巴结有效率 91 1% ( 4 1/ 4 5) ,其中CR 4 8 9% ( 2 2 / 4 5) ,PR 4 2 2 % ( 19/ 4 5)。结论 :颞浅动脉插管灌注化疗对晚期鼻咽癌近期疗效较好 。

Objective:To observe the effect and adverse reactions of intraarterial chemotherapy (IACT) in treatment of advanced nasopharyngeal carcinoma.Methods:THP 20 mg,d 1,DDP 30 mg,d 2-4 ,PYM 8 mg,d 5-9 .Three weeks for one cycle.Results:The overall effective rate of primary lesion was 90% (CR 20%,PR 70%),and 911%(CR 489%,PR 422%)of cervical lymph nodes.Conclusions: IACT is an effective way in treating advanced nasopharyngeal carcinoma and the harmful reactions are slight.