家族聚集性“血管瘤”临床分析及激光治疗效果评价

Clinical evaluation of laser efficacy on familial aggregation hemangioma

目的探讨家族聚集性“血管瘤”的家族分布特点和临床特征，提高诊治水平措施。方法回顾自2006年6月至2011年6月收治的“血管瘤”患者1202例，对具有家族聚集性者（36例）的临床资料、家族分布特点结合文献进行分析并对激光治疗效果进行评价。结果36例家族聚集性“血管瘤”，在1202例中的发生率为2．99％，男女比例1：1，父母辈患“血管瘤”9例，下一代的发生率为28．5％。家族聚集性“血管瘤”36例中，33例应用长脉冲1064nmNd：YAG激光和优化脉冲光联合治疗，有效率为100％。随访1年半以上无复发或加重现象。结论血管瘤可能存在遗传倾向；应用长脉冲1064nmNd：YAG激光和优化脉冲光联合治疗，可获得满意效果，应早期干预治疗。

Objective To investigate the distribution characteristics and clinical features of fa- milial aggregation hemangioma to improve the level of the diagnosis and treatment. Methods Total 1202 cases of vascular disease were treated in this department from June 2006 to June 2011. The clinical data and family distribution characteristics in 36 cases of familial aggregation hemangioma were analyzed and their effects of laser treatment were evaluated. Results 36 cases were familial aggrega- tion hemangioma, whose incidence was 2.99 M in 1202 cases of vascular disease cutis~ and the ratio of male to female was 1 ：1. There were 9 cases of parents suffering from hemangioma. But the incidence of the next generation suffering from vascular disease was 28.5 %. Among these 36 cases of familial aggregation hemangioma, 33 cases underwent the long pulse 1064 nm Nd ： YAG laser and optimized pulse light combination therapy. The effective rate was 100 0%. Conclusions There may be a genetic predisposition in hemangioma. The application of long pulse 1064 nm Nd ： YAG laser and optimized pulsed light treatment to hemangioma cutis can obtain satisfactory results. The intervention should be taken in early stage.