细胞周期素依赖性激酶、细胞周期调控与肝纤维化

Cyclin-dependent kinases,control of cell cycle and hepatic fibrosis

肝纤维化是多种肝脏疾病的共同病理学结局.在肝纤维化过程中,肝星状细胞(hepatic stellate cells,HSCs)发生活化,表型发生改变,使其具有收缩性、再生性,并能生成胶原成分.肝纤维化的发生发展与活化的HSCs的增殖情况有关;而细胞增殖情况则与细胞周期素依赖性激酶、细胞周期调控密切相关.但是,目前对与此相关的分子机制尚未明确.此综述就近年来与肝纤维化过程中细胞周期素依赖性激酶及细胞周期调控方面的研究加以总结,以揭示可能存在的引起肝纤维化的部分机制.

Multiple etiologies of liver disease lead to liver fibrosis by driving the activation of hepatic stellate cells（HSCs） into a myofibroblast-like phenotype that is contractile,proliferative and fibrogenic.Liver fibrosis is associated with the proliferation of HSCs,and the cell cycle of activated HSCs is abnormal.Cyclin-dependent kinases（CDKs） play essential roles in cell proliferation.However,the molecular mechanisms responsible for the abnormal proliferation of activated HSCs during hepatic fibrogenesis remain to be defined.Here we will review recent progress in understanding the associations among CDKs,the control of cell cycle and hepatic fibrosis,with an aim to reveal the potential mechanisms of hepatic fibrosis.