重视基于片段的药物发现技术

Emphasizing on the fragment-based drug discovery

基于片段的药物发现(FBDD)是将结构生物学、药物筛选、药物化学和分子模拟相整合的创制小分子药物的综合技术。本文简要介绍了FBDD的基本原理,并讨论了国外应用此技术推动新药研发的实例,旨在呼吁我国的众多药物研发大平台重视FBDD技术并加以应用。

The fragment-based drug discovery（FBDD） is a comprehensive technology, consisting of struc- tural biology, drug screening, medicinal chemistry, and molecular modeling. This overview concisely describes the basic principle of FBDD method and illustrates a few examples appealing to applying this method in China Drug in- novation.