前列腺素E_(1)与弥可保联合治疗糖尿病周围神经疾病疗效观察

Coeffect of PGE_(1) and mecobalamin on diabetic neuropathies

目的：观察前列腺Ｅ_1与弥可保联合应用对糖尿病周围神经病变的疗效。方法：８７例糖尿病周围神经病变患者随机分组对照观察，治疗组４９例给予前列腺素Ｅ_1２００ μｇ静脉点滴每日一次，同时每日肌注弥可保 ５００μｇ，共 ６周；对照组 ３８例，单用弥可保肌注，每日５００μｇ共６周。结果：治疗组痛觉过敏及感觉减退，有效率达６５％和７９％，明显高于对照组的４４％和５６％，Ｐ＜０．０５；神经传导速度改善的有效率也有一定程度的提高，Ｐ＜０．０５。结论：前列腺素Ｅ_1与弥可保联合应用可明显提高对糖尿病周围神经病变的疗效。

Objective:To investigate the coeffect of mecobalamin and prostaglandin E1(PGE1 ) on diabetic neuropathies.Methods:Eighty seven patients with diabetic neuropathies were involved in a randomized control clinical trial.49 cases were treated with mecobalamin (500 ug) intramuscu- larly and PGE1(200 ug) solved in normal saline (500 ml) intravenously every day for six weeks,38 cases only treated with mecobalamin (500 ug) intramuscularly everyday as control.Results:Six weeks after treatment,hyperalgia and hyperalgia and hypoesthesia were improved 65% and 79% in the therapy group,which were significantly higher than those in the controls (44% and 56%, P < 0.05). Combined therapy also benefited nerve conduction ve- locity to a better extent compared with the controls (P < 0.05). Conclusion:The curative effect of diabetic neuropathies could be significiently im - proved by the combination of PGE1 and mecobalamin.