右旋酮洛芬的抗炎作用

Anti-inflammatory effect of dexketoprofen

目的 研究右旋酮洛芬 (D KP)的抗炎作用。方法 采用二甲苯诱导的小鼠耳水肿、大鼠角叉菜胶诱发的足肿胀、大鼠棉球肉芽肿模型和大鼠佐剂性关节炎 (AA)模型。结果 D KP(5、10、2 0mg·kg-1)对二甲苯诱导的小鼠耳水肿有明显的抑制作用 ;D KP(2 5、5、10mg·kg-1)对大鼠角叉菜胶引起的足肿胀和棉球诱导的大鼠肉芽肿有明显的抑制作用 ;D KP(2 5、5、10mg·kg-1)对AA大鼠的继发性炎症有明显的抑制作用。结论 D KP可能具有良好的抗炎作用。

Objective\ To study anti-inflammatory effect of dexketoprofen (D-KP). Methods\ Ear swelling induced by dimethylbenzene in mice, foot paw swelling induced by carrageenin,gramuloma induced by cotton,and adjuvant arthritis in rats were adopted. Results D-KP(5,10,20 mg·kg -1) could significantly inhibit ear swelling induced by dimethylbenzene. D-KP(25,5,10 mg·kg -1) significantly inhibited carrageenin-induced foot paw swelling and cotton-induced gramuloma in rats. In AA rats, D-KP(25,5,10 mg·kg -1) significantly inhibited the secondory inflammatory reaction. Conclusion\ D-KP may have remarkable anti-inflammatory effect.