受体相互作用蛋白RIP1在乳腺癌的表达及其临床意义

Expression and Significance of Receptor Interacting Protein 1 in Breast Cancer

目的评价受体相互作用蛋白RIP1在乳腺癌的表达及与临床病理特征的关系。方法使用免疫组化SP法检测46例乳腺癌组织和相应癌旁组织中RIP1的表达状态,并结合临床病理特征如临床分期、病理分级、肿瘤大小、有无淋巴结转移进行统计学分析。结果 46例乳腺癌组织中,阳性表达的有30例,占65.2%,癌旁组织中阳性表达的只有13例,仅占28.3%,差异有统计学意义(P<0.01),癌组织中RIP1的阳性表达与病人的年龄、肿瘤大小、组织学类型无关,与临床分期、病理分级、有无淋巴结转移呈正相关,即癌组织中RIP1表达越高,病人临床分期病理分级越高、淋巴结转移越多。结论癌组织中RIP1表达增高是乳腺癌恶性程度较高的一个标志。

Objective To assess the expression status and clinical significance of receptor interactingprotein 1 in breast cancer tissues using immunohistochemistry assay. Methods IHC SP method was used to as- sess the expression status in 46 breast cancer tissues and adjacent normal breast tissues. The relationship be- tween expression of RIP1 and clinical pathological parameters, such as clinical stage, pathological grade and lymphatic metastasis was analyzed. Results Among 46 cancerous tissues, RIP1 was expressed positively in 30 cancerous tissues and the positive rate was 65.2%. However, RIP1 was only expressed in 13 adjacent normal breast tissues and the positive rate was only 28.3%. There had significant difference between the two groups. The positive rate of RIP1 in breast cancer tissues was positively correlated with the clinical stage, pathological grade and lymphatic metastasis,but was not related to patients＇ age,tumor size and histological types. Conclu- sion Increased expression of RIP1 is a molecular marker implying higher malignant degree in breast cancer.