降钙素原、超敏C反应蛋白及前清蛋白联合检测在儿童急性呼吸道感染中的应用价值

The Clinical Values of Combined Detection on Procalcitonin,High-sensitivity C-Reactive Protein and Prealbumin of Children Patients with Acute Respiratory Infection

目的探讨联合检测降钙素原(PCT)、超敏C反应蛋白(hs-CRP)及前清蛋白(PA)在儿童急性呼吸道感染中的诊断价值。方法对2011年1月至2012年6月期间本院急性呼吸道感染及非呼吸道感染就诊患儿进行PCT、hs-CRP及PA的检测,比较分析细菌性感染组、病毒性感染组及对照组各项指标的变化。结果细菌性感染组PCT及hs-CRP水平分别为(3.15±0.98)μg/L和(35.2±15.6)mg/L,均高于病毒性感染组及对照组;PA水平为(102.15±41.96)mg/L,低于病毒性感染组和对照组。差异有统计学意义(P<0.01)。细菌性感染组PCT及hs-CRP异常率分别为84.62%和80.00%,均明显高于病毒性感染组及对照组,差异有统计学意义(P<0.01)。结论联合检测急性呼吸道感染患儿PCT、hs-CRP及PA,有助于区分患儿是细菌感染,还是病毒感染,对于指导临床抗菌药物的应用有临床指导意义。

Objeetive To discuss the clinical values of combined detection on procalcitonin （PCT） , high-sensitivity C-reactive protein （hs-CRP） and prealbumin （PA） of children patients with acute respiratory infection. Methods The levels of PCT, hs-CRP and PA of children patients with acute respiratory infection from our hospital during January 2011 to June 2012 were tested and analyzed. Result The levels of PCT and hs-CRP in bacterial infection group were （3.15±0.98） μg/L and （35.2±15.6） mg/L, which were higher than those in viral infection group and control one, but the level of PA in bacterial infection group was （102.15±41.96） mg/L, which was lower than that in viral infection group and control one, with significant difference （P〈0.01） .The abnormal rates of PCT and hs-CRP in bacterial infection group were 84.62% and 80.00%, which were significantly higher than those in viral infection group and control one, with significant difference （P〈0.01） .Conclusion Enhancing the detection on PCT, hs-CRP and PA of children patients with acute respiratory infection contribute to distinguish whether they were infected by bacteria or virus, it is beneficial to guide the clinical use of antibiotics.