丙泊酚复合瑞芬太尼用于无痛人流的麻醉效果及安全性研究

Study on the Anesthetic Effect and Safety of Propofol combined with Remifentanil for Painless Artificial Abortion

目的研究丙泊酚复合瑞芬太尼在无痛人流麻醉中的效果及安全性。方法将进行无痛人流的112例患者随机分为两组,各56例。使用丙泊酚复合瑞芬太尼麻醉的为观察组,使用丙泊酚复合芬太尼麻醉的为对照组。通过术中体动次数、药物用量及术后清醒时间、腹痛、呼吸抑制等对麻醉效果及安全性进行评估,并进行组间比较及统计学分析。结果观察组患者麻醉效果优于对照组,差异具有显著性(P<0.05);术后清醒时间及腹痛情况优于对照组,差异具有显著性(P<0.05);呼吸抑制发生次数高于对照组,差异具有显著性(P<0.05)。结论丙泊酚复合瑞芬太尼在无痛人流麻醉的应用中具有效果显著、清醒快、并发症少等优势,但由于术中呼吸抑制发生次数较多,需加强对呼吸系统的监测。

Objective To study the effect of propofol combined with remifentanil in painless anesthesia and its safety. Methods 112 patients with painless induced abortion were randomly divided into two groups,each group of 56 cases. The observation group is＇the use of propofol and remifentanil anesthesia. The control group is the use of propofol and fentanyl anesthesia. To evaluate the clinical efticacy and safety of body movement, by number, dosage, awake time after operation, abdominal pain, respiratory depression, operation, and comparison between two groups and statistical analysis. Results Effect of anesthesia in the observation group were better than the control group, the difference was significant （P〈0.05）. Awake time and abdominal pain cases after operation of patients in the observation group were better than that in control group, the difference was significant （P〈0.05）. Inhibition of respiratory frequency of the observation group were higher than those in the control group, the difference was significant （P〈0.05）. Conclusion It has obvious effect, faster recovery, less complications and other advantages with propofol and remifentanil in painless anesthesia, but due to respiratory depression occurred more frequently in the operation, need to strengthen the monitoring of the respiratory system.