同型半胱氨酸与初发急性ST段抬高型心肌梗死患者冠状动脉病变程度的相关性研究

Study on the Relationship between Homocysteine and He severity of Coronary Artery Lesions in Patients with Primary Acute ST Segment Elevation Myocardial Infarction

目的分析血清同型半胱氨酸(Hcy)水平与非心力衰竭初发急性ST段抬高型心肌梗死患者冠状动脉病变程度有无相关性及其临床意义。方法选取非心力衰竭急性心肌梗死患者65例,对照组20名为我院体检中心健康体检者。入院次日晨空腹测定各组Hcy水平,将冠状动脉病变程度与Hcy水平进行相关性分析,并对不同梗死部位的Hcy水平进行比较。所得数据采用SPSS 19.0统计软件进行分析。计量资料采用(均数±标准差)表示,应用t检验进行分析。Hcy与冠状动脉评分之间采用Pearson相关分析。P<0.05为显著性差异。结果急性心肌梗死组Hcy水平显著高于对照组(P<0.001)。血浆Hcy水平与冠状动脉病变评分呈正相关关系,相关系数为r=0.695。结论在排除心力衰竭因素后,Hcy水平越高,急性心肌梗死患者冠状动脉病变程度越重。Hcy测定有助于急性心肌梗死患者的危险分层及预后判断。

Objeetive To analyze the serum homocysteine （Hey） level and non heart failure in primary acute myocardial infarction patients with ST segment elevation extent of coronary artery lesions have no correlation and its clinical significance. Methods 65 patients with non heart failure, acute myocardial infarction, 20 patients in the control group for the health examination center. The fasting levels were measured in each Hey, the severity of coronary artery lesion and the level of Hcy correlation analysis, and compares the different infarct Hey level. The obtained data were analyzed using SPSS 19.0 statistical software. Measurement data using （mean ~ standard deviation） said, using t test analysis. Using Pearson correlation analysis between Hey and coronary artery score. P 〈 0.05 was significant difference. Results Acute myocardial infarction group, Hcy level was significantly higher than that of the control group （P 〈 0.001）. Correlation between plasma Hcy level and coronary lesion score was positively, the correlation coefficient is r =0.695. Conelusion In the exclusion of failure factors, the higher the Hey level, the more severe lesions of coronary artery in patients with acute myocardial infarction degree. Hey determination of risk stratification and prognosis is helpful for patients with acute myocardial infarction.