阿尔茨海默病患者精神行为障碍与ApoE、LRP基因多态性的关联性分析

The Correlation Analysis of AD Patients’ Mental and Behavioral Disorders and ApoE and LRP Gene Polymorphism

目的探讨阿尔茨海默病(AD)患者精神行为障碍与ApoE、LRP基因多态性的关联性分析。方法收集2010年8月至2012年10月AD患者80例,正常对照者80例。结果ε4/4在偏执和妄想观念、幻觉及行为紊乱、攻击方面与其他基因型差异有统计学意义,AD患者ApoE基因频率分布与正常对照组比较,差异有统计学意义(P<0.05)。两组LRP的基因型频率和等位基因频率差异无统计学意义(P>0.05)。结论 AD患者精神行为障碍与ApoE基因频率多态性存在一定联系,ApoEε4是AD的风险基因,LRP基因多态性和AD的关系有待进一步研究探讨。

Objective To study the Alzheimer＇s disease （AD） patients mental and behavioral disorders and ApoE gene polymorphism and LRP the correlation analysis. Methods Collect in August 2010 to October 2012 AD patients in 80 cases, 80 cases of normal controls, the AD disease pathology behavior rating scale （BEHAVE - AD） behavior evaluation, the spirit of PLR in ApoE and LRP gene parting. Results In the ApoE gene type, ε 4/4 in paranoid and delusion concept, illusion and behavior disorders, attack and other genotype difference have statistical significance, in patients with AD ApoE gene frequency distribution and the normal control group, the difference is statistically significant （P〈0.05）. The two groups of LRP genotype frequency and allele frequency difference was not statistically significant （P〉0.05） in patients with AD. Conclusion Mental and behavioral disorders and ApoE gene frequency polymorphism there is contact, ApoE epsilon4 AD is the risk of LRP gene, gene polymorphism and AD relationship needs further study.