期刊文献+

西妥昔单抗治疗晚期结肠癌1例报告及文献复习 被引量:1

下载PDF
导出
摘要 结直肠癌是常见的消化道恶性肿瘤。确诊为结直肠癌的患者中有50%~60%会发生转移。晚期结直肠癌以全身治疗为主,20世纪90年代后期开始应用奥沙利铂、伊立替康等药物后,晚期结直肠癌的治疗有效率及生存期均显著改善。Ⅳ期结肠癌或复发的患者可以同时发生肝转移或肺转移。单纯肝转移或肺转移患者仍有治愈可能。15%~25%的结直肠癌患者同时伴有肝转移,其中80%~90%的患者初次评估时肝转移灶无法手术切除。通过积极的转化治疗,部分患者可获得手术机会。
出处 《癌症进展》 2013年第3期280-283,共4页 Oncology Progress
  • 相关文献

参考文献10

  • 1Kemeny N.Management of liver metastases from colorectal cancer[J].Oncology,2006,20:1161-1176; 1179-1180; 1185-1186.
  • 2Cunningham D,Humblet Y,Siena S,et al.Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer[J].N Engl J Med,2004,351 (4):337-345.
  • 3Van Cutsem E,Kohne CH,Hitre E,et al.Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer[J].N Engl J Med,2009,360 (14):1408-1417.
  • 4Bokemeyer C,Bondarenko I,Makhson A,et al.Fluorouracil,leucovorin,and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer[J].J Clin Oncol,2009,27 (5):663-671.
  • 5Maughan TS,Adams RA,Smith CG,et al.Addition of cetuximab to oxaliplatin-based fires-line combination chemotherapy for treatment of advanced colorectal cancer:results of the randomized phase 3 MRC COIN trial[J].Lancet,2011,377 (9783):2103-2114.
  • 6Tveit KM,Guren T,Glimelius B,et al.Phase Ⅲ trial of cetuximab with continuous or intermittent fluorouracil,leucovorin,and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer:the NORDIC-Ⅷ study[J].J Clin Oncol,2012,30(15):1755-1762.
  • 7Martin-Martorell P,Roselló S,Rodrigue-Braun E,et al.Biweekly Biweekly cetuximab and irinotecan in advanced colorectal cancer patients progressing after at least one previous line of chemotherapy:results of a phase Ⅱ single institution trial[J].Br J Cancer,2008,99 (3):455-458.
  • 8Schmoll H J,Van Cutsem E,Stein A,et al.ESMO Consensus Guidelines for management of patients with colon and rectal cancer.A personalized approach to clinical decision making[J].Ann Oncol,2012,23 (10):2479-2516.
  • 9Maithel SK,Ginsberg MS,D'Amico F,et al.Natural history of patients with subcentimeter pulmonary nodules undergoing hepatic resection for metastatic colorectal cancer[J].JAmCollSurg,2010,210 (1):31-38.
  • 10H(o)yer M,Swaminath A,Bydder S,et al.Radiotherapy for liver metastases:a review of evidence[J].Int J Radiat Oncol Biol Phys,2012,82 (3):1047-1057.

同被引文献10

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部