Krebs型锑钨酸盐Na_(10)[Sb_2W_(20)Co_2O_(70)(H_2O)_6]·34H_2O的合成、结构及抗肿瘤活性研究

Synthesis,structure and antitumor activities of the Krebs-type Tungstoantimonate Na_(10)[Sb_2W_(20)Co_2O_(70)(H_2O)_6]·34H_2O

常规水溶液法合成了含钴的锑钨酸盐Na10[Sb2W20Co2O70(H2O)6].34H2O(1).单晶X-射线衍射表明,化合物1含2个三缺位的[SbW9]半单元,2个半单元通过2个WO3簇和2个CoO2簇相连.2个WO3簇和2个CoO2簇形成了1个四金属夹心带,2个WO3簇位于夹心带的中间,2个CoO2簇位于夹心带的两边,该结构为典型的Krebs型结构.体外抗肿瘤活性实验结果表明,化合物1对2种人体肿瘤细胞系—卵巢癌细胞(SK-OV-3)和肝癌细胞(SMMC-7721)—有明显的抑制活性.

The Krebs-type Tungstoantimonate Na10[Sb2W20Co2O70（H2O）6]·34H2O 1 has been obtained in an aqueous solution.Single-crystal X-ray analysis shows that compound 1 crystallizes in triclinic crystal system,space group p-1 with a=1.334（5） nm,b=1.334（5） nm,c=1.811（5） nm,α = 85.278（5） °,β=71.108（5） °,γ=63.823（5） °.Polyanion 1 contains two tri-lacunary moiety units which are joined by two WO3 and two CoO2 groups forming a sandwich belt of four metal atoms.Compound 1 exhibits a typical Krebs structure.The result of antitumor activities in vitro shows that the title compound 1 has presented significant inhibitory actions on two human tumor cell lines,ovarian cancer cell line（SK-OV-3） and liver cancer cell line（SMMC-7721）.