Survivin基因和热休克蛋白在膀胱癌中的表达以及相互关系临床分析

The clinical analysis of Survivin gene and heat shock protein expression in bladder cancer as well as the relationship

目的探究Survivin基因和热休克蛋白在膀胱癌中的表达及其相互关系在临床上的应用分析。方法采用免疫组织化学的方法检测我院150例膀胱移形细胞癌和12例正常膀胱组织中的Survivin基因和热休克蛋白的表达,检测两者在病理分级、临床分期和初发、复发中的表达。结果膀胱癌患者中Survivin基因和热休克蛋白表达均为阳性70例,表达均为阴性的有19例,但在正常组织中Survivin基因和热休克蛋白几乎没有表达。结论 Survivin基因和热休克蛋白在膀胱癌患者的组织中的特异表达增加,会随着临床病理分级和肿瘤的复发的增加而增加,但在正常的组织中的基本没有表达,因此在膀胱癌患者中的表达具有正相关性。

[ Objective ] To explore the Survivin gene and heat shock protein expression in bladder cancer and their relationship to clinical application analysis. [ Methods ] Using immunohistochemistry method to detect the expression of Survivin gene in our hospital 150 cases of bladder transitional cell carcinoma and 12 cases of normal bladder tissue and heat shock protein detection both in the pathological grade, clinical stage and the onset expression in relapse. [ Results ] Survivin gene and heat shock protein expression was positive in 70 cases of bladder cancer patients, the expression of the 19 cases were negative, but almost no expression of Survivin gene and heat shock protein in normal tissues. [ Conclusion ] Survivin genes and heat shock proteins in patients with bladder cancer tissue specific expression increased, will increase with increasing clinical pathological grade and tumor recurrence, but basically not expressed in normal tissues, and therefore in the bladder expression in cancer patients with a positive correlation.