Annexin A7及其共相关蛋白研究进展

Advance in study on annexin A7 and it's associated proteins

膜联蛋白(annexin A7)是一种能促进膜融合的钙依赖性磷脂结合蛋白,近来研究表明其在多种肿瘤的发生、发展、转归中起重要作用。Annexin A7可与多种蛋白(如半乳糖凝集素3,抗药蛋白,凋亡相关基因2,死亡结构域沉默子等)相互作用。Annexin A7及其共相关蛋白的研究有助于阐明Annexin A7在肿瘤细胞发生、发展机制中的作用,有利于发现新的肿瘤治疗靶点。

Annexin A7 is a phospholipid binding protein which plays a role in promotion of membrane fusion in a Ca2＋-dependent manner. Recent studies suggest that it also plays an important role in tumor occurrence, progress and turnover. There is evidence that annexin A7 can interact with multiple proteins, including galectin-3, sorcin, apoptosis-linked gene 2, silencer of death domains, etc. The studies on annexin A7 and its associated proteins will help to elucidate the role of annexin A7 in tumor occurrence and progression as well as provide novel targets for tumor treatment.