美常安联合利动治疗老年功能性便秘的疗效分析

Effects of Medilac-S combined with Lactulose on treating functional constipation in geriatrics

目的观察美常安(Medilac-s)联合利动(Lactulose)治疗老年功能性便秘的临床疗效。方法采用前瞻性随机对照研究,将90例老年慢性功能性便秘患者随机分为A组(联合治疗组):口服美常安(500mg/次,2次/d)联合利动(15ml/次,2次/d);B组(单用美常安组):口服美常安(500mg/次,2次/d);C组(单用利动组):口服利动(15ml/次,2次/d),在治疗2周和4周后分别观察平均每周排便次数、每次排便时间和大便性状的变化,评价便秘相关症状及治疗副作用并做对比分析,疗程共4周。结果A组总有效率为86.67%,明显优于B组(43.3%)及C组(53.33%)(P<0.05);与B、C组比较,A组在观察终末期每周排便次数、每次排便时间、大便形态评分以及便秘相关症状方面也有显著性差异(P<0.05),治疗后均未发现严重副作用。结论美常安联合利动有效缓解老年功能性便秘的症状,疗效明显,安全可靠。

Objective To evaluate the effects of Medilac-S combined with Lactulose on treating functional constipation in geriatrics.Methods 90 cases（60 to 75 years old） suffering from functional constipation and meeting all the inclusion criteria were recruited and randomly divided into three groups of each 30 cases： group A（combination therapy group,given Medilac-S,500mg/time,2 times/day combined with Lactulose,15ml/time,2 times/day）,group B（Medilac-S singlely treated group,administered with Medilac-S,500mg/time,2 times/day）,and group C（Lactulose singlely treated group,administered with Lactulose,15ml/time,2 times/day）.The changes of weekly bowel movements,stool form score,average time spent on toilet for bowel evacuation and VAS score of associated symptoms of functional constipation were observed after two and four weeks treating,and the treatment lasted for four weeks.Results After 4 weeks’ clinical therapy,the total effective rates of remission were 86.67%,43.33%,53.33% in group A,B,C respectively.Compared with group B or C,group A showed a significant increase in mean weekly bowel movements and mean stool form score,meanwhile,a significant decrease in mean average time spent on toilet for bowel evacuation and VAS score of associated symptoms of functional constipation（P＆lt;0.05）.Conclution Clinical effects of Medilac-S combined with Lactulose on treating functional constipation in geriatrics are better than that of single drug,and the therapeutic benefits are obvious,safe,worthy of clinical application.