2009-2012年我院血培养中病原菌的分布及耐药情况分析

Analysis of the Distribution and Drug Resistance of Pathogens in Blood Cultures of Our Hospital from 2009 to 2012

目的:了解该院血培养阳性标本中病原菌的分布和耐药性,以指导临床合理用药。方法:采用回顾性分析方法,对该院2009-2012年血培养阳性标本中病原菌的分布、构成及耐药性进行统计、汇总。结果:临床分离的1 128株病原菌中,革兰阳性菌占79.52%,革兰阴性菌占18.71%,真菌占1.77%。分离数列前3位的病原菌分别为表皮葡萄球菌(42.64%)、溶血葡萄球菌(13.21%)、肺炎克雷伯菌(6.56%)。主要革兰阳性菌对万古霉素和利奈唑胺高度敏感,未出现耐药菌株;主要革兰阴性菌耐药率最低的是亚胺培南,其次是阿米卡星。结论:血培养分离株对常用抗菌药物耐药现象严重,提示应高度重视合理使用抗菌药物,以提高临床治疗效果。

OBJECTIVE：To investigate the distribution and drug resistance of pathogens from positive blood culture in our hospital in order to guide clinical rational use of drugs.METHODS：By using retrospective analysis method,the distribution,composition and drug resistance of pathogens from positive blood culture were summarized statistically in our hospital from 2009 to 2012.RESULTS：Among 1 128 strains of isolated pathogens,Gram-positive bacteria accounted for 79.52%,Gram-negative bacteria accounted for 18.71% and fungi accounted for 1.77%.Top 3 pathogens were Staphylococcus epidermidis（42.64%）,Staphylococcus haemolyticus（13.21%）,Klebsiella pneumoniae（6.56%）.Results from the sensitivity test confirmed that Gram-positive bacteria were highly sensitive to vancomycin and linezolid,and no drug-resistant strain was found.Gram-negative bacteria strains were the least resistant to imipenem,followed by amikacin.CONCLUSIONS：The drug resistance of pathogens from positive blood culture is serious.It is suggested that antibacterial agents be used rationally so as to enhance clinical therapeutic efficacy.