我院2012年117例药品不良反应报告分析

Analysis of 117 Cases of ADR Reports in Our Hospital in 2012

目的:了解该院药品不良反应(ADR)报告发生情况。方法:收集该院2012年上报ADR监测网并已通过重庆市ADR监测中心审核的117例ADR报告,根据患者年龄、性别、ADR累及器官或系统及临床表现、药品种类、给药途径等进行分类统计与分析。结果:60岁以上患者ADR发生率最高,占47.01%;ADR累及器官或系统以皮肤及其附件损害最常见,占30.77%;涉及ADR的药品种类排名第1位的为中药制剂,占24.79%;抗菌药物引发的ADR中,β-内酰胺类构成比最高,占48.15%;给药途径引起的ADR中,静脉滴注最常见,占93.16%。结论:应加强临床医务工作者对ADR的认知度,尽量减少或避免ADR的发生,促进临床合理用药,减少医患纠纷的发生。

OBJECTIVE：To investigate ADR reports in our hospital.METHODS：According to ADR monitoring network in 2012,117 ADR cases reported by our hospital and checked by Chongqing ADR Monitoring Center were analyzed statistically in respects of age,gender,organs or systems involved in ADR,clinical manifestation,the type of drugs,route of administration,etc.RESULTS：The incidence of ADR in patients aged more than 60-year-old was the highest,accounting for 47.01%;the most common symptoms of organs or systems involved in ADR were lesion of skins and its appendants,accounting for 30.77%;TCM preparation ranked the first among all drug types,accounting for 24.79%;the proportion of β-lactam was the highest among antimicrobial drugs,accounting for 48.15%;intravenous infusion was the most common ADR-inducing route of administration,accounting for 93.16%.CONCLUSIONS：The awareness of medical workers about ADR should be strengthened to reduce or avoid the occurrence of ADR and the medical disputes,improve rational drug use in the clinic.