临床药师对2例妇科恶性肿瘤患者保留生育能力术后化疗前使用GnRHa的药学监护

Pharmaceutical Care of GnRHa before Chemotherapy for 2 Gynecology-oncology Patients after Fertility Preservation Operation

目的：探讨妇科恶性肿瘤患者保留生育能力术后化疗前使用促性腺激素释放激素类似物（GnRHa）治疗过程中临床药师的作用。方法：针对2例卵巢恶性肿瘤保留生育能力术后需辅以化疗巩固治疗的患者,临床药师为患者选择目前常用的GnRHa长效制剂醋酸戈舍瑞林缓释植入剂3.6 mg,皮下注射,每28 d 1次保护患者卵巢功能。结果：2例患者分别在使用醋酸戈舍瑞林缓释植入剂3-4个周期后出现停经,一名患者主诉有大量出汗、烦躁不适,另一名患者无明显不适主诉,2例均顺利完成了全程化疗。结论：临床药师与医师协作,可在保证化疗效果的同时为患者选择对生殖系统影响最小的化疗方案。

OBJECTIVE：To explore the role of clinical pharmacist during the therapy process of GnRHa for gynecology-oncology patients after fertility preservation operation.METHODS：For 2 selected gynecology-oncology patients who received chemotherapy after fertility preservation operation,clinical pharmacists adopted hypodermic injection of GnRHa analogue long-acting preparation Goserelin acetate implant 3.6 mg every 28 day to protect ovarian function of the patient.RESULTS：2 patients entered menopause after 3-4 cycle of treatment of Goserelin acetate implant.One case complained of profuse sweating,fidgets and discomfort;the other case didn＇t complain of obvious discomfort.Both cases completed the chemotherapy smoothly.CONCLUSIONS：Clinical pharmacist cooperating with physicians can ensure therapeutic efficacy and select the optimal chemotherapy regimen for patient to minimize reproductive system injury.