急性脑梗死患者血清IL-8、IL-17、IL-18水平变化

Changes of serum levels of IL-8,IL-17,IL-18 in patients with acute cerebral infarction

目的探讨急性脑梗死患者血清白介素(IL)-8、IL-17、IL-18的水平变化及意义。方法采用ELISA法检测89例急性脑梗死患者和45例健康对照者血清中IL-8、IL-17、IL-18的水平,比较2组差异。结果急性脑梗死患者血清中IL-8、IL-17、IL-18的水平均高于健康对照者,差异有统计学意义(P<0.05)。结论炎症反应参与了急性脑梗死的病理生理过程,IL-8、IL-17、IL-18水平的变化可用于监测急性脑梗死的病情严重程度。

Objective To investigate the changes of serum levels of interleukin（IL）-8,IL-17,IL-18 and their significances.Methods The serum levels of IL-8,IL-17,and IL-18 were detected by ELISA in the 89 patients with acute cerebral infarction and 45 healthy controls,and the differences between the two groups were compared.Results The serum levels of IL-8,IL-17,IL-18 in the patients with acute cerebral infarction were higher than those in the healthy controls,the difference was statistically significant（P0.05）.Conclusion Inflammatory response can induce acute cerebral infarction;the level changes of IL-8,IL-17,and IL-18 can be used for monitoring the severity of acute cerebral infarction.