臭氧关节腔内注射治疗老年退行性骨性关节炎的临床研究

Clinical study of regressive osteoarthritis of knee in old by ozone intraarticular injection

目的:观察臭氧关节腔内注射治疗老年退行性膝骨性关节炎的临床疗效。方法:门诊收治老年性骨性膝关节炎患者120例,随机分为A、B、C 3组。A组单纯应用混合消炎镇痛液(曲安奈德、利多卡因和生理盐水混合液10ml);B组患者首先应用0.25%利多卡因5ml进行局部麻醉,之后给予臭氧25ug浓度共20ml;C组患者联合2种治疗方法,3组均治疗5周。A、B、C 3组经治疗后分别观察1周后、5周后、12周后患者的疼痛评分缓解情况。结果:A、B、C 3组经治疗后疼痛评分均有缓解,治疗前后疼痛评分统计学分析有差异;经治疗后第1周和第5周以及第12周的疼痛评分组间比较具有统计学差异,其中A、B组未见统计学差异,B、C,A、C组间第1周第5周及第12周的疼痛评分对照均具有统计学差异。各组患者的膝关节功能均得到改善。结论:臭氧对关节腔内注射治疗老年退行性膝骨性关节炎有显著疗效,联合小荆量皮质类固醇应用效果更佳。

Objective： To observe the clinical effect of osteoarthritis of Knee by ozone intraarticular injection. Methods： 120 cases came to our clinic service dignosised regressive osteoarthritis of Knee, were divided into ABC three groups randomly. Group A was given intraartictdar injection by mixed analgesia fluid （triamcinolone acetonide 8rag ＋ lidocaine O. 25% ＋ physiological saline 10ml） ; group B, given lidocaine 0.25% 5ml for local anesthesia firstly,was intraarticular injected by ozone 25ug 20ml; group C combined A with B. All cases have continued treatment for five weeks. Pain relieved scores were recorded in the first week, the fifth week and the twelfth week. Results： All cases had pain relieved after treatment. There were significant statistic difference between pretherapy and post -treatment among three groups in the first week,the fifth week and the twelfth week,and there was no statistic difference between A and B. Significant statistic difference between B and C, A and C had been found in all three different times. Joint function improved happened to all cases. Conclusion： Regressive osteoarthritis of knee will have significant effection by ozone intraarticular injection, there would be well by combining corticosteroids by small dose.