宫内感染与早产儿脑损伤相关性探讨

Explore of relationship between intrauterine infection and brain injury of preterm infants

目的：探讨早产儿脑损伤与宫内感染的关系。方法：将123例早产儿根据胎盘病理检查结果分成2组，有绒毛膜羊膜炎的48例作为研究组，无绒毛膜羊膜炎的75例作为对照组。新生儿生后3～7天进行头颅影像学检查，并在纠正胎龄40用时予新生儿行为神经测定（NBNA）。通过头颅影像学及NBNA评分观察2组脑损伤的发生情况。对脑损伤患儿进行早期干预。追踪随访至1周岁。结果：研究组脑损伤的发生率达31．25％（15／48），与对照组5．33％（4／75）相比，差异有统计学意义（P〈0．001）。研究组NBNA评分〈35分占39．58％（19／48），与对照组9．33％（7／75）相比，2组差异显著（P〈0．001）。研究组NBNA得分35．17±3．61，与对照组36．92±2．37相比，差异显著（P〈0．001）。结论：宫内感染与早产儿脑损伤的发生有一定关系。

Objective： To explore the relationship between intrauterine infection and the brain injury of preterm infants. Methods： 123 preterm infants were divided into two groups according to the results of histological methods. Infants with maternal chorioamnionitis was 48 ,the control group was 75. Totally infants were checked by head imaging from 3 -7 clays after born and were scored by the Neonatal Behavioral Neurological Assessment （NBNA） after correcting age 40 weeks. Early interventions were carried out in the infants with brain injury. All infants were followed up until one year old. Results： In the group with maternal chorioamnionitis, the case rate of brain injury was 31.25% ,NBNA score was 35.17 ± 3.61,39.58% was below 35 score,which are significantly higher than the control group, （P 〈 0.001 ）. Conclusion： The intrauterine infection might be associate with the brain injury of preterm infants.