普贝生用于足月妊娠促宫颈成熟的护理探讨

Discussion on efficacy and safety of continuously-released dinoprostone suppositories prostaglandin E2 suppositories for cervical ripening in pregnancies

目的:探索普贝生——控释前列腺素E_2栓剂用于足月妊娠促宫颈成熟、催产的有效性和安全性。方法:采用随机抽查、对照研究的方法,50例为研究组,予阴道放置普贝生观察;50例对照组,予静脉滴注催产素观察。比较2组孕妇宫颈Bishop评分,分娩情况,对胎儿及新生儿的影响。结果:研究组孕妇用药后2、4、8、12小时宫颈Bishop评分分别为4.0±1.3、4.2±1.2、6.0±1.1和7.6±1.7,明显高于对照组3.7±1.4、3.8±0.8、4.1±1.1和4.6±1.2(P<0.01)。研究组孕妇临产发动时间、阴道分娩率明显高于对照组(P<0.01)。产程中研究组胎儿窘迫发生率、出生后1分钟、5分钟Apgan评分与对照组之间无统计学差异(p>0.05)。宫缩过度刺激是普贝生的主要副作用,但取药后可立即好转。结论:普贝生是一种有效、安全的促宫颈成熟的药物。

Objective： To explore the efficacy and safety of continuously - released dinoprostone suppositories prostaglandin E2 suppositories for cervical ripening in pregnancies. Methods：Using randomized placebocontrolled study,50 cases as study group, received a dinoprostone suppositories inserting into vaginal,while 50 eases as control group received oxytocin through transvenous injecting. The cervical Bishop score, vaginal delivery rate, fetal and neonatal condition were compared between the two groups. Results：Cervical score of study group were significantly higher than control group in 2,4,8,12 hours after treatment （p 〈 0.01 ）. The time of labor starting and vaginal delivery rate of study group were significantly higher than control group （p 〈 0.01 ）. The incidence of fetal distress, cervical score of 1 minute and 5minute after birth had not significant difference between the two groups. Overstimulation of cervix was its main side effects ,but improved immediately after drug removal. Conclusion：Dinoprostone suppositories is effective and safe in producing cervical ripening.