水飞蓟宾治疗高甘油三酯血症的自身对照研究——附80例报告

A self control clinical test of hypertriglyceridemia treated by silybum:80 cases report

目的:求证水飞蓟宾降低高甘油三酯血症患者血清甘油三酯(TG)含量的作用和程度,并观察其对人体肝、肾功能的影响。方法:随机选择80例有高甘油三酯血症(TG含量≥2.50 mmol/L)的住院或门诊心脑血管病或肝病患者,均给于口服水飞蓟宾葡甲胺片(江苏中兴药业有限公司生产)200 mg/次,2次/d,连服30～60 d。分别于服药前、服药后30 d和(或)服药后60 d检查空腹(禁食12 h后)血脂、血糖以及肝、肾功能,并记录不良反应。结果:有55例服药30 d后进行了血脂复查,其中15例(27.3%)为显效(血TG水平下降≥40%),27例(49.1%)为有效(血清TG下降≥20%,但<40%);49例服药60 d时进行了复查,显效25例(51.0%)、有效15例(30.6%)。总有效率服药30d时为76.4%,60 d时为81.6%。血总胆固醇含量的平均值服药后稍有下降,但差异无统计学意义(P>0.05),血高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)的含量均无明显改变。服药后患者空腹血糖含量、肝功能、肾功能均无明显变化;未见明显不良反应。结论:水飞蓟宾可有效降低高甘油三酯血症患者的血甘油三酯水平而无肝肾功能损害或其他毒副反应,且可减轻或治愈原有损害的肝功能,建议将其列为高甘油三酯血症的一线药物。

Objective： To certify if the drug silybum could decrease the blood triglycerides level of hypertriglyceridemia patients,and how adverse reactions would be produced on their liver and renal function or elsewhere.Methods： A total of 80 cases of hypertriglyceridemia（TG≥2.50 mmol/L） with cardiac cerebral vascular disease,or hepatic disease from out-patient department or admitted patients,were given silybum 0.2 bid orally to 30 or/and 60 days.Their blood lipids,fast blood glucose,liver and renal function were checked before treatment and one/or two months after treatment.And what else adverse reactions happened after treatment,if any,were all recorded.Results： 1.The effect of decreasing blood TG.： Evident（blood TG decreased≥40%）：27.3% in the patients rechecked after one month,and 51% after two months.Effective（blood TC decreased≥20%,but＆lt; 40%）： 49.1% in the patients one month after treatment,and 30.6% after two months.Inefficacy（blood TC decreased＆lt;20%）：23.6% after one month and 18.4% after two months respectively,with the total efficacy 76.4% after one month and 81.6% after two months.2.There were a few decrease of the level of blood total cholesterol（TC） after treatment both after one or two months,but were not significant statistically（P＆gt;0.05）,and there were evidently no significant difference of HDL-C or LDL-C between their after treatment and before treatment levels.3.There were not any adverse influence to liver or renal function,and fasting blood glucose,whenever after taking the drug one or two months;on the contrary,the drug can improve or even treat the abnormal liver function such as to decrease the elevated blood transaminase prominently.4.All patients hadn’t any noxious adverse action to be recorded.Conclusion： Silybum can decrease the bood triglyceride level of hypertriglyceridemia patients,without any adverse influence to liver or kidney function,or other toxic action.And silybum can even improve or treat the abnormal liver function,to decrease abnormal elevated blood transaminase evidently,so that it could be suggested to be used as the first line drug to treat the hypertriglyceridemia.