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DNA损伤与动脉粥样硬化 被引量：2

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摘要 动脉粥样硬化（atherosclerosis,AS）是心血管疾病发病的主要病理基础。典型的AS病变表现为大、中动脉某些部位内膜局限性增厚,其中有大量脂质沉积、单核细胞和淋巴细胞浸润、
作者 达静静 钱民章
机构地区 遵义医学院生物化学与分子生物学教研室
出处 《江苏大学学报（医学版）》 CAS 2013年第3期270-273,276,共5页 Journal of Jiangsu University：Medicine Edition
关键词 DNA损伤 动脉粥样硬化 氧化应激 γH2AX 共济失调毛细血管扩张突变蛋白
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献39

  • 1Corral-Debrinski M,Stepien G,Shoffner JM,et al.Hypoxemia is associated with mitochondrial DNA dam-age and gene induction.Implications for cardiac disease[J].JAMA,1991,266(13):1812-1816.
  • 2Cervelli T,Borghini A,Galli A,et al.DNA damage andrepair in atherosclerosis:current insight and future per-spectives[J].Int J Mol Sci,2012,13(12):16929-16944.
  • 3Gray K,Bennett M.Role of DNA damage in atheroscle-rosis-bystander or participant?[J].Biochem Pharma-col,2011,82(7):693-700.
  • 4Mahmoudi M,Mercer J,Bennett M.DNA damage andrepair in atherosclerosis[J].Cardiovasc Res,2006,71(2):259-268.
  • 5Corral-Debrinski M,Shoffner JM,Lott MT,et al.Asso-ciation of mitochondrial DNA damage with aging andcoronary atherosclerotic heart disease[J].Mutat Res,1992,275(3/6):169-180.
  • 6Hatzistamou J,Kiaris H,Ergazaki M,et al.Loss ofheterozygosity and microsatellite instability in humanatherosclerotic plaques[J].Biochem Biophys Res Com-mun,1996,225(1):186-190.
  • 7Botto N,Rizza A,Colombo MG,et al.Evidence forDNA damage in patients with coronary disease[J].Mu-tat Res,2001,493(1/2):23-30.
  • 8Matturri L,Cazzullo A,Turconi P,et al.Chromosomalalterations in atherosclerotic plaques[J].Atherosclero-sis,2001(3);15:755-761.
  • 9Cooke MS,Evans MD,Dizdaroglu M,et al.OxidativeDNA damage:Mechanisms,mutation,and disease[J].FASEB J,2003,17(10):1195-1214.
  • 10Martinet W,Knaapen MW,De Meyer GR,et al.Ele-vated levels of oxidative DNA damage and DNA repairenzymes in human atherosclerotic plaques[J].Circula-tion,2002,106(8):927-932.

二级参考文献18

  • 1Moghadasian M H. Experimental atherosclerosis: a historical overview[J]. Life Sci, 2002, 70(8):855-865.
  • 2Botto N, Rizza A, Colombo M G, et al. Evidence for DNA damage in patients with coronary artery disease[ J]. Murat Res, 2001, 493(1-2) : 23-30.
  • 3Rojas A, Figueroa H, Re L, et al. Oxidative stress at the vascular wall mechanistic and pharmacological aspects[J]. Arch Med Res, 2006, 37(4): 436-448.
  • 4Mercer J R, Cheng KK, Figg N, et al. DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome[J]. Circ Res, 2010, 107(8): 1021-1031.
  • 5Song Y, Leonard S W, Traber M G, et al. Zinc deficiency affect DNA damage, oxidative stress, antioxidant defense, and DNA repair in rats[J]. J Nutr, 2009, 139(9) : 1629-1631.
  • 6Mahmoudi M, Mercer J, Bennett M. DNA damage And repair in athemsclerosis[ J]. Cire Res,2006, 7( 1 ) : 259-268.
  • 7Mercer J R, Cheng K K, Figg N, et al. DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome[J]. Circ Res, 2010, 107(8): 1021-1031.
  • 8Mahley R W. The role of dietary fat and cholesterol in atherosclerosis and lipoprotein metabolism [ J ]. West J Med, 1981, 13,1(1) : 34-42.
  • 9Banath J P, Klokov D, MacPhail S H, et al. Residual gammaH2AX loci as an indication of lethal DNA lesions [J]. BMC Cancer, 2010, 10:4.
  • 10Kinner A, Wu W, Staudt C, et al. 3,H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin [ J]. Nucleic Acids Res, 2008, 17(36) :5678-5694.

共引文献6

同被引文献6

引证文献2

二级引证文献7

江苏大学学报（医学版）
2013年 第3期

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