血清肿瘤标记物联合检测对原发性肝癌患者诊断价值

Diagnosis value discussion of combined detection of serum tumor markers for primary liver cancer

目的探讨肿瘤标志物甲胎蛋白(AFP)、γ-谷氨酰转肽酶(γ-GT)、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA199)在原发性肝癌中的阳性率及联合检测对原发性肝癌诊断的临床价值。方法采用化学发光法对115例原发性肝癌患者、117例肝硬化患者和182例健康体检者检测血清AFP、γ-GT、CEA、CA125、CA199,并进行对照分析。结果 AFP、γ-GT、CEA、CA125、CA199在原发性肝癌组的阳性率分别为77.4%、36.5%、42.6%、56.5%、69.6%。5项肿瘤标志物联合检测在原发性肝癌组的阳性率最高为95.7%。结论肿瘤标志物联合检测可提高原发性肝癌的诊断率,对原发性肝癌的鉴别诊断有重要的临床意义。

Objective To study clinical diagnosis value of the positive rates and combined detection of tumor marker AFP,GGT,CEA,CA125 and CA199 in patients with primary liver cancer. Methods AFP,GGT,CEA,CA125 and CA199 in serum of 115 patients with primary liver,117 patients with liver cirrhosis and 182 healthy subjects were detected by chemiluminescence and contrast analysis was carried on. Results The positive rates of AFP,GGT,CEA,CA125,CA199 were 77. 4%,36. 5%,42. 6%,56. 5%,69. 6% respectively in patients with primary liver cancer. The highest positive rate of combined assays of five kinds of tumor markers for primary liver cancer was95. 7%. Conclusion The diagnosis rate of primary liver cancer could be increased with combined assays of tumor markers and it was important to differentiated diagnosis of primary liver cancer.