摘要
碳青霉烯类抗生素自一出现就表现出较广的抗菌谱和较强的抗菌活性,由于其对β-内酰胺酶稳定,引起研究人员广泛的关注,至今对该化合物的研究已取得了很大的进展。文章主要从产β-内酰胺酶、膜通透性降低、主动外排泵的亢进以及作用靶位的改变等4个方面讨论了碳青霉烯类耐药菌的耐药机制。碳青霉烯类抗生素在临床上应用广泛,该类化合物的耐药细菌也越来越多。在复杂的耐药机制背景下,探索相关耐药机制将有助于加速发现更有效的化合物。
After the clinical application of carbapenem antibiotics, they had demonstrated a broad-antibacterial- spectrum and strong antibacterial activity; besides, they were stable to various β-lactamases discovered. So they had attracted a great attension of research scientists on studying their characteristics and clinical potentials. In order to develop carbapenem antibiotics with higher antimierobial activity, different mechanisms of the carbapenem-resistant bacteria had been discussed. Up to date, considerable progress on this anti- biotic had been achieved. In this review ,the production of β-lactamase ,loss of oprin,overproduction of efflux pumps and the change of the target site were discussed and summarized in mechanism of carbapenem-resistant bacteria. The bacterial resistance of carbap- enem antibiotics,which were widely used in clinic, had been more and more serious. The drug resistance mechanism of carbapenem antibiotics also became more and more complex, and exploration of the resistance mechanism of drug-resistant bacteria could be used to speed the discovery of more effective compounds.
出处
《药物生物技术》
CAS
2013年第4期373-376,共4页
Pharmaceutical Biotechnology
关键词
耐碳青霉烯
机制
Β-内酰胺酶
Carbapenem-resistantance
Mechanism
β-Lactamase
