待产孕妇血清中PAEs暴露水平及其与胎儿生长发育的相关性研究

Study on the correlation between exposure level of PAEs in serum of predelivery women and growth and development of fetuses

目的:了解待产孕妇血清中两种邻苯二甲酸酯(PAEs)水平,探讨血清PAEs水平与胎儿生长发育的关系。方法:收集150例武汉市某三级医院待产孕妇血清,采用反相高效液相色谱分析法(HPLC)检测其血清邻苯二甲酸丁苄酯(BBP)和邻苯二甲酸二丁酯(DBP)的含量;新生儿出生后记录其体长和体重,采用多元线性回归分析孕妇血清BBP、DBP含量与新生儿的体长、体重的相关性。结果:150例研究对象BBP检出率为62.7%,BBP最大值为85.09μg/ml,最小值为1.39μg/ml,中位数为0.64μg/ml;DBP检出率为61.3%,DBP最大值为60.89μg/ml,最小值为2.15μg/ml,中位数为0.32μg/ml。相关性单因素分析和相关性多因素分析结果均显示150例胎儿的生长发育与BBP、DBP浓度具有相关性,并差异有统计学意义。结论:大多数孕妇体内均可检测出BBP和/或DBP,且其在血清中的含量与胎儿生长发育有关。

Objective： To understand the levels of two kinds of phthalic acid ester （PAEs） in serum of predelivery women, explore the relationship between serum PAEs levels and growth and development of fetuses. Methods： The serum samples of 150 predelivery women were collected from a tertiary hospital in Wuhan city, HPLC was used to detectthe contents of serum butyl benzyl phthalate （BBP） and di - n - butyl phthalate （DBP） ; the body height and body weight of the neonates were recorded after dehvery; multivariate linear regression analysis was adopted to analyze the correlation between contents of serum BBP, DBP and body height, body weight of neonates. Results： The detection rate of BBP in 150 study objects was 62. 7%, the maximum value, minimum value, and median of BBP were 85.09 ixg/ml, 1.39 Ixg/ml, and 0. 64 Ixg/ml, respectively; the detection rate of DBP was 61.3% , the maximum value, minimum value, and median of DBP were 60. 89 ~g/ml, 2. 15 txg,/ml, and O. 32 ~g/ml, respectively. Univa- riate and multivariate correlation analysis showed that there was a significant correlation between growth and development of 150 fetuses and BBP, DBP concentrations. Conclusion： BBP and/or DBP can be detected in most pregnant women, and the serum contents of BBP and DBP are correlated with growth and development of theii~ fetuses.