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闽东宫颈癌普查中HPV E6/E7 mRNA及DNA的应用研究 被引量：2

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摘要 目的:分析超薄液基细胞学(LCT)技术在宫颈癌筛查中的应用。方法:采集554例LCT标本,检测HPV E6/E7 mRNA,同时检测HPV E6/E7 DNA;对结果的总体分布情况及在不同细胞学级别分布情况行统计学分析。结果:以病理结果为标准,43例中不同级别的HPV E6/E7 mRNA,DNA检测情况比较,差别无统计学意义;以细胞学检测为标准,231例不同级别中HPV E6/E7 mRNA及DNA检测情况,除ASCUS外,其余级别两种检测方法差别无统计学意义;34例ASCUS标本同时行病理活检,以CIN为阳性结果,两种检测方法对阳性结果的判读,差别无统计学意义。结论:宫颈癌筛查中检测HPV E6/E7mRNA对于宫颈癌筛查具有一定的临床意义。
作者 余兰 周伦顺 刘桐宇 黄宝英 富显果 缪韵仪 陈惠华 卢少玲 Lulu Zhang
机构地区 福建医科大学附属宁德市医院 福建省肿瘤医院妇科 University of Florida Shands Cancer Center
出处 《中国妇幼保健》 CAS 北大核心 2013年第25期4241-4243,共3页 Maternal and Child Health Care of China
关键词 人乳头瘤病毒 MRNA DNA疾病筛查 E6 E7
分类号 R711.3 [医药卫生—妇产科学]
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参考文献7

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同被引文献39

  • 1Katzenellenbogen RA,Vliet-Gregg P,Xu M,et al. Cyto- plasmic poly (A) binding proteins regulate telomerase ac- tivity and cell growth in human papillomavinls type 16 E6-expressing keratinocytes [J]. J Virol,2010,84 (24), 12934-12944.
  • 2Van Doorslaer K,Tan Q,Xirasagar S,et al. The Papillo-mavirus Episteme:a central resource for papillomavirus sequence data and analysis. [J]. Nucleic Acids Res, 2013,41(24):571-578.
  • 3Chung HS,Hahm C,Lee M. Comparison of the clinical performances of the AdvanSure HPV scening real-time PCR,the Abbott real-time high-risk HPV test,and the Hybrid Capture high-risk HPV DNA test for cervical can- cer screening[J]. Virol Methods, 2014,205 : 57-60.
  • 4Mirzaie-Kashani E,Bouzari M,Talebi A,et al. Detection of human papillomavirus in chronic cervicitis,cervical adeno- carcinoma,intraepithelial neoplasia and squamus cell car- einoma[j]. Jundishapur J Microbiol, 2014,7(5): 9930-9935.
  • 5Martins AE,Lucena-Silva N,Garcia RG,et al. Prognostic evaluation of DNA index in H1V-HPV co-infected women cervical samples attending in reference centers for HIV- AIDS in Recife.[J]. PLoS One, 2014,9(8) : 104801.
  • 6Acera A,Manresa JM,Rodriguez D,et al. Analysis of three strategies to increase screening coverage for cervical cancer in the general population of women aged 60 to 70 years:the CRICERVA study[J]. BMC Womens Health,201d, 14: 86.
  • 7Entiauspe LG,Silveira M,Nunes EM,et al. High inci- dence of oncogenic HPV genotypes found in women from Southern Brazil[J]. Braz J Microbiol, 2014,45(2) : 689-694.
  • 8Phillips CK, Hruby GW, Durak E, et al. Tissue response to surgical energy devices[J].Urology, 2008,71 (4) : 744-748.
  • 9刘立鸿,汪凯,张富春,马正海.人乳头瘤病毒(HPV)致癌机制研究进展[J].生命科学,2008,20(2):295-299. 被引量：14
  • 10郝敏,卞美璐.人乳头瘤病毒L1蛋白功能及其临床应用[J].中国实用妇科与产科杂志,2010,26(5):352-355. 被引量：17

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中国妇幼保健
2013年 第25期

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