睡眠时间与脑梗死关系的病例对照研究

A case-control study on the duration of sleeping and cerebral infarction

目的探讨睡眠时间与脑梗死的关系。方法采用病例对照研究方法选择2011年12月至2012年12月哈尔滨医科大学第二附属医院1037例脑梗死住院患者作为病例组，以同期健康体检的1205名非脑血管病者作为对照组，采用统一的调查问卷。数据分析采用）χ2、u检验和多因素非条件logistic回归模型。结果以睡眠时间6—8h者为基准相比，调整年龄、性别、BMI、腰臀围比值、吸烟、饮酒、高血压、糖尿病、冠心病以及血脂指标后，睡眠时间〈6h者患脑梗死的风险增加（OR=2．81，95％CI：1．68-4．70）；睡眠时间〉8h者与脑梗死无关联（OR=0．76，95％CI：0．48-1．20）。按照性别分层后，睡眠时间〈6h与脑梗死的相关性仍然存在，且女性睡眠时间〈6h者脑梗死发生风险高于男性，OR值分别为5．58（95％CI：1．78—17．52）、2．00（95％CI：1．10—3．64）。结论睡眠不足可能是脑梗死的危险因素。

Objective To explore the relationship between duration of sleeping and cerebral infarction. Methods A case-control study involved 1037 cerebral infarction patients admitted by the Second Affiliated Hospital of Harbin Medical University, December 2011-December 2012 as cases. Another 1205 adults free from cerebro-vascular diseases who had undergone physical examination in the hospital at the same period, were served as controls. All the subjects were interviewed with unified questionnaire. Chi-square test, u-test and multivariate logistic regression analysis were performed. Results After adjustment for potential confounding factors including age, sex, body mass index, wrist-hip ratio, smoking, alcohol intake, hypertension, diabetes mellitus, coronary artery disease and lipid parameters, data from the multivariate logistic regression analysis showed that the risk of cerebral infarction was greater in people who slept less than 6 hours per night than those who slept between 6 hours and 8 hours per night, with an odds ratio （95%CI） as 2.81 （95%C1： 1.68-4.70）. There was no significant association between factor as ＇sleeping longer than 8 hours/pre day＇ and cerebral infarction. Through the subgroup analysis, data showed that the association between ＇ shorter than 6 hour sleep/night＇ and cerebral infarction consistently exsited, across the categories of sex, and the degree of association was greater in women than in men, with the odds ratio as 5.58 （95% CI： 1.78-17.52） and 2.00（95%CI： 1.10-3.64） respectively. Conclusion Short sleeping duration might increase the risk of developing cerebral infarction.