期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PLGA多孔支架的制备及在基因传递系统中的应用研究进展 被引量：2

Research Progress on Preparation of Porous PLGA Scaffold and Its Application in Gene Delivery System
原文传递
导出
摘要 高分子合成材料聚乳酸-羟基乙酸(PLGA)其生物降解速率可控,生物相容性好,力学强度高,已被广泛应用于三维基因传递系统。综述近年来常用的PLGA多孔支架制备方法及其对支架参数的影响以及PLGA支架在基因传递系统中的应用研究。 Poly-lactide-co-glycolide （PLGA）, a synthesized polymer with controllable biodegradation rate, good biocompatibility and desirable mechanical strength, has been widely applied in 3 D gene deliver- y system. The recent progress in the research of the commonly used preparation methods for porous PLGA scaffolds, their influence on the scaffold parameters and the application of PLGA scaffolds in gene delivery system was reviewed.
作者 付敏 徐希明 余江南
机构地区 江苏大学药学院
出处 《药学进展》 CAS 2013年第8期376-382,共7页 Progress in Pharmaceutical Sciences
基金 国家自然科学基金(81072586 81273470) 江苏省"333"工程资助项目(BRA2010138)
关键词 聚乳酸-羟基乙酸 多孔支架 三维基因传递系统 PLGA porous scaffold 3D gene delivery system
分类号 R318.08 [医药卫生—生物医学工程] Q782 [生物学—分子生物学]
  • 相关文献

参考文献35

  • 1Pan Z, Ding J D. Poly (lactide-co-glycolide) porous scaf- folds for tissue engineering and regenerative medicine [ J]. Inte~Cace Focus ,2012,2(3 ) :366-377.
  • 2Beloti M M, Sicchieri L G, de Oliveira P T, et al. The influence of osteoblast differentiation stage on bone forma- tion in autogenously implanted cell-based poly( lactide-co- glycolide) and calcium phosphate constructs [ J]. Tissue Eng A ,2012,18 (9/10) :999-1005.
  • 3McUsic A C, Lamba D A, Reh T A. Guiding the morpho- genesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds [ J ]. Biomaterials, 2012,33 (5) : 1396-1405.
  • 4Im G I, Kim H J, Lee J H. Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5 ,-6 and-9 ) genes[J]. Biomaterials ,2011,32(19) :4385-4392.
  • 5Kasuya J, Sudo R, Tamogami R, et al. Reconstruction of 3D stacked hepatocyte tissues using degradable, micro- porous poly ( D, L-lactide-co-glycolide ) membranes [ J ]. Biomaterials ,2012 ,33 ( 9 ) :2693-2700.
  • 6Dorati R, Colonna C, Genta I, et al. Effect of porogen on the physico-chemical properties and degradation perfor- mance of PLGA scaffolds [ J ]. Polym Degrad Stabil, 2010,95 (4) :694-701.
  • 7Barbanti S H, Zavaglia C A C, Rezenda Duek E A D. Effect of salt leaching on PCL and PLGA (50/50) resor- bable scaffolds [ J ]. Mater Res-lbero-Am J, 2008,11 ( 1 ) : 75-80.
  • 8Lee J H, Oh J H, Kim M R, et al. Evaluation of in vitro spermatogenesis using poly ( D, L-lactic-co-glycolic acid ) (PLGA)-based macroporous biodegradable scaffolds [J] J Tissue Eng Regen Med,2011,5(2) :130-137.
  • 9Massumi M, Abasi M, Babaloo H, et al. The effect of topography on differentiation fates of matrigel-coated mouse embryonic stem cells cultured on PLGA nanofi- brous scaffolds [ J ]. Tissue Eng A, 2012, 18 ( 5/6 ) : 609-620.
  • 10Xin X, Hussain M, Mao J J. Continuing differentiation of human mesenchymal stem cells and induced chondrogenic and osteogenic lineages in electrospun PLGA nanofiber scaffold [ J ]. Biomaterials, 2007,28 ( 2 ) : 316-325.

同被引文献16

引证文献2

二级引证文献7

药学进展
2013年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部