分光光度法测定富马酸比索洛尔

Spectrophotometric Determination of Bisoprofolfumarat Based on a Charge Transfer Reaction

摘要：基于药物和显色剂之间荷移反应，建立了一种对富马酸比索洛尔含量检测的分光光度法。在水介质中，富马酸比索洛尔与茜素红在室温中放置15rain后形成1：1型荷移配合物，其λmax为535nm，表观摩尔吸光系数为6．76×10^3L／（moi·cm），线性范围为10～100mg／L，线性回归方程为A=0．085＋0．00712c，相关系数r一0．99904，相对标准偏差RSD为0．449／6（n=6）。将该方法用于富马酸比索洛尔片含量的测定，回收率为在98．3％～102．6％之间。

Based on the charge transfer reaction between arug anu method for the determination of bisoprofolfumarat was developed. Bisoprofolfumarat can react with aliza- rin red to form 1 ~ 1 complex after being placed for 15 minutes in room temperature,which gives a maxi- mum absorption peak at 535μm. The molar absorptivity of the complex was 6.76× 103/（mol · cm） the linear range was 10-100mg/L, and the linear equation was A 0.085 ＋0. 00712c, with r=0. 99904. the RSD was 0.44% （n=6）. When it was applied for the determination of bisoprofolfumarat tablets,the re- coveries were between 98.3%-102.60%.