Pd催化的有机氟化反应研究进展

Palladium-catalyzed fluorination reactions

近几年来,Pd催化的有机反应是有机合成领域的热点,Pd化合物在催化氟化反应中具有高活性、高选择性,引起研究者们的极大关注。本文综述了近年来Pd催化的氟化反应进展,分别从亲核氟化、亲电氟化以及不对称氟化反应三个方面综述了近年来Pd催化形成C—F键的研究进展,并对各类反应的反应条件、反应选择性、产率以及机理的研究进行了讨论和总结。特别是对合成含氟芳香化合物的研究,从反应机理、反应条件和催化配体等方面做了详细的介绍,对脂肪族含氟化合物进行了简要的概述。在此基础上,展望了Pd催化在氟化反应中的一些应用前景,指出反应机理的深入探讨和催化配体的选择是今后的研究重点和主要方向。

The study on palladium-catalyzed reactions is one of the frontier areas in organic synthesis chemistry. Palladium compounds, which show high activity and selectivity as catalysts in the fluorination reactions, have attracted more attentions. The main progress made in the field of palladium-catalyzed fluorination during the last decade is reviewed. Moreover, efforts in studying Pd-catalyzed organic transformations have been focused on nucleophilic fluorination, electrophilic fluorination and asymmetric reaction. In addition, the reaction conditions, selectivity, yields and mechanisms are discussed and summarized. The researches on palladium catalysts for the synthesis of aryl fluorides are also reviewed, especially, the catalytic mechanism, the reaction conditions and ligand. The reaction system for the synthesis of alkyl fluorides is briefly discussed. Moreover, the outlook for further prospect of palladium-catalyzed fluorination is given in this paper. The further research work should be focused on the investigation of reaction mechanism and the selection of catalyst ligand.